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Page 1
Gene Silencing and Haploinsufficiency of Csk Increase Blood Pressure.
Lee HJ, Kang JO, Kim SM, Ji SM, Park SY, Kim ME, Jigden B, Lim JE, Hwang SY, Lee YH, Oh B. Lee HJ, et al. PLoS One. 2016 Jan 11;11(1):e0146841. doi: 10.1371/journal.pone.0146841. eCollection 2016. PLoS One. 2016. PMID: 26751575 Free PMC article.
Injection of siRNAs for mouse homologs Csk, Ulk3, and Cyp1a2 (negative control) showed reduced target gene mRNA levels in vivo. However, Csk siRNA only increased blood pressure while Ulk3 and Cyp1a2 siRNA did not change it. Further, blood pressure in Csk+/- heterozy …
Injection of siRNAs for mouse homologs Csk, Ulk3, and Cyp1a2 (negative control) showed reduced target gene mRNA levels in vivo. Howev …
The genetic risk for hypertension is lower among the Hungarian Roma population compared to the general population.
Soltész B, Pikó P, Sándor J, Kósa Z, Ádány R, Fiatal S. Soltész B, et al. PLoS One. 2020 Jun 17;15(6):e0234547. doi: 10.1371/journal.pone.0234547. eCollection 2020. PLoS One. 2020. PMID: 32555714 Free PMC article.
Estimating the prevalence of cardiovascular diseases (CVDs) and risk factors among the Roma population, the largest minority in Europe, and investigating the role of genetic or environmental/behavioral risk factors in CVD development are important issues in countries where …
Estimating the prevalence of cardiovascular diseases (CVDs) and risk factors among the Roma population, the largest minority in Europ …
Blood pressure and hypertension are associated with 7 loci in the Japanese population.
Takeuchi F, Isono M, Katsuya T, Yamamoto K, Yokota M, Sugiyama T, Nabika T, Fujioka A, Ohnaka K, Asano H, Yamori Y, Yamaguchi S, Kobayashi S, Takayanagi R, Ogihara T, Kato N. Takeuchi F, et al. Circulation. 2010 Jun 1;121(21):2302-9. doi: 10.1161/CIRCULATIONAHA.109.904664. Epub 2010 May 17. Circulation. 2010. PMID: 20479155
Significant associations were replicated for 7 loci-CASZ1, MTHFR, ITGA9, FGF5, CYP17A1-CNNM2, ATP2B1, and CSK-ULK3-with any or all of these 3 traits: systolic blood pressure (P=1.4x10(-14) to 0.05), diastolic blood pressure (P=1.9x10(-12) to 0.05), and hypertension (P=2.0x …
Significant associations were replicated for 7 loci-CASZ1, MTHFR, ITGA9, FGF5, CYP17A1-CNNM2, ATP2B1, and CSK-ULK3-with any or all of …
Genome-wide association study of blood pressure and hypertension.
Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ, Dehghan A, Glazer NL, Morrison AC, Johnson AD, Aspelund T, Aulchenko Y, Lumley T, Köttgen A, Vasan RS, Rivadeneira F, Eiriksdottir G, Guo X, Arking DE, Mitchell GF, Mattace-Raso FU, Smith AV, Taylor K, Scharpf RB, Hwang SJ, Sijbrands EJ, Bis J, Harris TB, Ganesh SK, O'Donnell CJ, Hofman A, Rotter JI, Coresh J, Benjamin EJ, Uitterlinden AG, Heiss G, Fox CS, Witteman JC, Boerwinkle E, Wang TJ, Gudnason V, Larson MG, Chakravarti A, Psaty BM, van Duijn CM. Levy D, et al. Nat Genet. 2009 Jun;41(6):677-87. doi: 10.1038/ng.384. Epub 2009 May 10. Nat Genet. 2009. PMID: 19430479 Free PMC article.

When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium (n = 34,433), four CHARGE loci attained genome-wide significance (P < 5 10(-8)) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3,

…
When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium (n = 34,433), four CHARGE loci a …
The association between genetic risk score and blood pressure is modified by coffee consumption: Gene-diet interaction analysis in a population-based study.
Miranda AM, Steluti J, Norde MM, Fisberg RM, Marchioni DM. Miranda AM, et al. Clin Nutr. 2019 Aug;38(4):1721-1728. doi: 10.1016/j.clnu.2018.07.033. Epub 2018 Aug 4. Clin Nutr. 2019. PMID: 30119983
The GRS was calculated based on SNPs in previous GWAS [CYP1A1/CYP1A2 (rs2470893, rs2472297); CPLX3/ULK3 (rs6495122); MTHFR (rs17367504)]. Multiple logistic regression analysis were performed to estimate the associations between GRS with high BP, and both, high systolic BP …
The GRS was calculated based on SNPs in previous GWAS [CYP1A1/CYP1A2 (rs2470893, rs2472297); CPLX3/ULK3 (rs6495122); MTHFR (rs1736750 …
Effects of established blood pressure loci on blood pressure values and hypertension risk in an Algerian population sample.
Lardjam-Hetraf SA, Mediene-Benchekor S, Ouhaibi-Djellouli H, Meroufel DN, Boulenouar H, Hermant X, Hamani-Medjaoui I, Saidi-Mehtar N, Amouyel P, Houti L, Goumidi L, Meirhaeghe A. Lardjam-Hetraf SA, et al. J Hum Hypertens. 2015 May;29(5):296-302. doi: 10.1038/jhh.2014.81. Epub 2014 Sep 18. J Hum Hypertens. 2015. PMID: 25231511
Genetic variants were considered both individually and when combined as genetic predisposition scores (GPSs) for systolic BP (SBP), diastolic BP (DBP) and HTN risk. The SNPs in CYP1A1-ULK3, HFE and SH2B3 were significantly associated with BP and/or HTN. ...
Genetic variants were considered both individually and when combined as genetic predisposition scores (GPSs) for systolic BP (SBP), diastoli …
Genetic variations in CYP17A1, CACNB2 and PLEKHA7 are associated with blood pressure and/or hypertension in She ethnic minority of China.
Lin Y, Lai X, Chen B, Xu Y, Huang B, Chen Z, Zhu S, Yao J, Jiang Q, Huang H, Wen J, Chen G. Lin Y, et al. Atherosclerosis. 2011 Dec;219(2):709-14. doi: 10.1016/j.atherosclerosis.2011.09.006. Epub 2011 Sep 16. Atherosclerosis. 2011. PMID: 21963141
We genotyped 7 variants in CYP17A1, PLEKHA7, CACNB2, ATP2B1, TBX3-TBX5, CSK-ULK3 and SH2B3 reported by the previous GWAs on Europeans. All analyses were performed in an additive genetic model. ...
We genotyped 7 variants in CYP17A1, PLEKHA7, CACNB2, ATP2B1, TBX3-TBX5, CSK-ULK3 and SH2B3 reported by the previous GWAs on Europeans …
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.
Fox ER, Young JH, Li Y, Dreisbach AW, Keating BJ, Musani SK, Liu K, Morrison AC, Ganesh S, Kutlar A, Ramachandran VS, Polak JF, Fabsitz RR, Dries DL, Farlow DN, Redline S, Adeyemo A, Hirschorn JN, Sun YV, Wyatt SB, Penman AD, Palmas W, Rotter JI, Townsend RR, Doumatey AP, Tayo BO, Mosley TH Jr, Lyon HN, Kang SJ, Rotimi CN, Cooper RS, Franceschini N, Curb JD, Martin LW, Eaton CB, Kardia SL, Taylor HA, Caulfield MJ, Ehret GB, Johnson T; International Consortium for Blood Pressure Genome-wide Association Studies (ICBP-GWAS); Chakravarti A, Zhu X, Levy D. Fox ER, et al. Hum Mol Genet. 2011 Jun 1;20(11):2273-84. doi: 10.1093/hmg/ddr092. Epub 2011 Mar 4. Hum Mol Genet. 2011. PMID: 21378095 Free PMC article.
We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. ...
We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-U …